1、國(guó)家重大科學(xué)研究計(jì)劃項(xiàng)目（973）：重大疾病相關(guān)的若干重要難檢活性小分子細(xì)胞內(nèi)納米傳感研究，No.2013CB933800, 2013-2017。2、國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目：活細(xì)胞內(nèi)分子事件過程示蹤的熒光成像探針的探索性研究No.21035003, 2011 -2014。3、國(guó)家自然科學(xué)基金科學(xué)儀器基礎(chǔ)研究專項(xiàng)：適用于單細(xì)胞內(nèi)活性小分子物種檢測(cè)的熒光分析儀No.21035003, 2013-2016。 唐波教授現(xiàn)已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Funct. Mater., Anal.Chem., Biomaterials, Lab Chip, Chem.Commun., Chem. Eur. J.等雜志發(fā)表SCI論文240余篇，影響因子大于5.0的論文有90余篇，引用5000余次。代表性論文有：1. Wei Zhang, Wei Liu, Ping Li*, Haibin Xiao, Hui Wang, and Bo Tang*. A Fluorescence Nanosensor for Glycoproteins with Activity Based on the Molecularly Imprinted Spatial Structure of the Target and Boronate Affinity. Angew. Chem. Int. Ed., 2014, 53, 12489-12493.2. Wen Zhang, Ping Li, Fan Yang, Xiufen Hu, Chuanzhi Sun, Wei Zhang, Dezhan Chen, and Bo Tang*. Dynamic and Reversible Fluorescence Imaging of Superoxide Anion Fluctuations in Live Cells and in Vivo. J. Am. Chem. Soc., 2013, 135, 14956-14959.3. Na Li, Chenyang Chang, Wei Pan, Bo Tang*. A Multicolor Nanoprobe for Detection and Imaging of Tumor-Related mRNAs in Living Cells. Angew. Chem. Int. Ed., 2012, 51, 7426-7430.4. Bo Tang*, Fabiao Yu, Ping Li, Lili Tong, Xia Duan, Ting Xie, and Xu Wang, A Near-Infrared Neutral pH Fluorescent Probe for Monitoring Minor pH Changes: Imaging in Living HepG2 and HL-7702 Cells. J. Am. Chem. Soc., 2009, 131, 3016-3023.5. Bo.Tang*, Yanlong Xing, Ping Li, Ning Zhang, Fabiao Yu, and Guiwen Yang , A Rhodamine-Based Fluorescent Probe Containing a Se-N Bond for Detecting Thiols and Its Application in Living Cells. J. Am. Chem. Soc., 2007, 129, 11666-11667.6. Yu-Bin Dong,* Peng Wang, Jian-Ping Ma, Xia-Xia Zhao, Bo Tang* and Ru-Qi Huang, Coordination Driven Nanosized Lanthanide ‘Molecular Lantern’ with Tunable Luminescent Properties. J. Am. Chem. Soc., 2007, 129, 4872-4873.7. Yu-Bin Dong,* You-Yun Jiang, Jie Li, Jian-Ping Ma, Feng-Ling Liu, Bo Tang,* Ru-Qi Huang, and Stuart R. Batten, Temperature-Controlled Synthesis of Metal-Oragnic Frameworks Based on Acyclic Crown Ether Bridging Tetradentate Ligand with Bidirectional Coordination Donors. J. Am. Chem. Soc., 2007, 129, 4520-4521.8. Yu-Bin Dong,* Qiang Zhang, Li-Li Liu, Jian-Ping Ma, Bo Tang* and Ru-Qi Huang, Cu(C24H22N4O3)CH2Cl2: A Breathing Discrete Metallamacrocycle Showing Selective Reversible Guest Adsorption with Retaining Single-Crystallinity. J. Am. Chem. Soc., 2007, 129, 1514-1515.9. Na Li, Zhengze Yu, Wei Pan, Yaoyao Han, Tingting Zhang, and Bo Tang*. A Near-Infrared Light-Triggered Nanocarrier with Reversible DNA Valves for Intracellular Controlled Release. Adv. Funct. Mater., 2013, 23, 2255-2262.10. Xu Wang, Juan Sun, Weihong Zhang, Xiaoxu Ma, Jianzheng Lv and Bo Tang*. A near-infrared ratiomateric fluorescent probe for rapid and highly sensitive imaging of endogenous hydrogen sulfide in living cells. Chem. Sci., 2013, 4, 2551-2556.11. Kehua Xu, Mingming Qiang, Wen Gao, Ruixian Su, Na Li, Yan Gao, Yanxia Xie, Fanpeng Kong and Bo Tang*. A Near-infrared reversible fluorescent probe for real-time imaging of redox status changes in vivo. Chem. Sci., 2013, 4, 1079-1086.12. Hui Xu, Qian Li, Lihua Wang, Yao He, Jiye Shi, Bo Tang* and Chunhai Fan*. Nanoscale optical probes for cellular imaging. Chem.Soc. Rev., 2014, 43, 2650-2661.13. Wen Gao, Lifei Ji, Lu Li, Guanwei Cui, Kehua Xu, Ping Li and Bo Tang*. Bifunctional combined Au-Fe2O3 nanoparticles for induction of cancer cell-specific apoptosis and real-time imaging. Biomaterials, 2012, 33, 3710-3718.14. Yu Ma, Hao Su, Xuan Kuang, Xiangyuan Li, Tingting Zhang, and Bo Tang*. Heterogeneous Nano Metal-Organic Framework Fluorescence Probe for Highly Selective and Sensitive Detection of Hydrogen Sulfide in Living Cells. Anal. Chem., 2014, 86, 11459-1146315. Haiyun Liu, Lu Li, Qian Wang, Lili Duan, and Bo Tang*. Graphene Fluorescence Switch-Based Cooperative Amplification: A Sensitive and Accurate Method to Detection MicroRNA. Anal. Chem., 2014, 86, 5487-5493.16. Lu Li, Qian Wang, Jie Feng, Lili Tong, and Bo Tang*. Highly Sensitive and Homogeneous Detection of Membrane Protein on a Single Living Cell by Aptamer and Nicking Enzyme Assisted Signal Amplification Based on Microfluidic Droplets. Anal. Chem., 2014, 86, 5101-5107.17. Na Li, Yanhua Li, Yaoyao Han, Wei Pan, Tingting Zhang, and Bo Tang*. A Highly Selective and Instantaneous Nanoprobe for Detection and Imaging of Ascorbic Acid in Living Cells and in Vivo. Anal. Chem., 2014, 86, 3924-3930.18. Ping Li, Wen Zhang, Kexiang Li, Xiao Liu, Haibin Xiao, Wei Zhang, and Bo Tang*. Mitochondria-Targeted Reaction-Based Two-Photon Fluorescent Probe for Imaging of Superoxide Anion in Live Cells and in Vivo. Anal. Chem., 2013, 85, 9877-9881.19. Lu Li, Feifei Gao, Jian Ye, Zhenzhen Chen, Qingling Li, Wen Gao, Lifei Ji, Ruirui Zhang, and Bo Tang*. FRET-Based Biofriendly Apo-GOx-Modified Gold Nanoprobe for Specific and Sensitive Glucose Sensing and Cellular Imaging. Anal. Chem., 2013, 85, 9721-9727.20. Haiyun Liu, Lu Li, Lili Duan, Xu Wang, Yanxia Xie, Lili Tong, Qian Wang, and Bo Tang*. High Specific and Ultrasensitive Isothermal Detection of MicroRNA by Padlock Probe-Based Exponential Rolling Circle Amplification. Anal. Chem., 2013, 85, 7941-7947.21. Wei Pan, Huijun Yang, Tingting Zhang, Yanhua Li, Na Li*, and Bo Tang*. Dual-Targeted Nanocarrier Based on Cell Surface Receptor and Intracellular mRNA: An Effective Strategy for Cancer Cell Imaging and Therapy. Anal. Chem., 2013, 85, 6930-6935.22. Xuan Kuang, Yu Ma, Hao Su, Jine Zhang, Yu-Bin Dong, and Bo Tang*. High-Performance Liquid Chromatographic Enantioseparation of Racemic Drugs Based on Homochiral Metal-Organic Framework. Anal. Chem., 2014, 86, 1277-1281.23. Zhenzhen Chen, Qingling Li, Qianqian Sun, Hao Chen, Xu Wang, Na Li, Miao Yin, Yanxia Xie, Hongmin Li and Bo Tang*. Simultaneous Determination of Reactive Oxygen and Nitrogen Species in Mitochondrial Compartments of Apoptotic HepG2 Cells and PC12 Cells Based On Microchip Electrophoresis–Laser-Induced Fluorescence. Anal. Chem., 2012, 84, 4687-4694.24. Ping Li, Shan Zhang, Nannan Fan, Haibin Xiao, Wen Zhang, Wei Zhang, Hui Wang, and Bo Tang*. Quantitative Fluorescence Ratio Imaging of Intralysosomal Chloride Ions with Single Excitation/Dual Maximum Emission. Chem. Eur. J., 2014, 20, 11760-11767.25. Xu Wang, Jianzheng Lv, Xueying Yao, Yong Li, Fang Huang, Mengmeng Li, Jie Yang, Xiuyun Ruan and Bo Tang*. Screening and investigation of a cyanine fluorescent probe for simultaneous sensing of glutathione and cysteine under single excitation. Chem. Commun., 2014, 50, 15439-15422.26. Sujuan Ye, Yanying Wu, Wen Zhang, Na Li and Bo Tang*. A sensitive SERS assay for detecting proteins and nucleic acids using a triple-helix molecular switch for cascade signal amplification. Chem. Commun., 2014, 50, 9409-9412.27. Wen Gao, Wenhua Cao, Huaibin Zhang, Ping Li, Kehua Xu and Bo Tang*. Targeting lysosomal membrane permeabilization to induce and image apoptosis in cancer cells by multifunctional Au-ZnO hybrid nanoparticles. Chem. Commun., 2014, 50, 8117-8120.28. Na Li, Huijun Yang, Wei Pan, Wei Diao and Bo Tang*. A tumour mRNA-triggered nanocarrier for multimodal cancer cell imaging and therapy. Chem. Commun., 2014, 50, 7473-7476.29. Ping Li, Haibin Xiao, Yinfang Cheng, Wen Zhang, Fang Huang, Wei Zhang, Hui Wang and Bo Tang*. A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH. Chem. Commun., 2014, 50, 7184-7187.30. Hongyan Zhang, Yanhong Wang, Qingling Li, Fumiao Zhang and Bo Tang*. A size amplified immune magnetic microbeads strategy in circulating tumor cells rapid detection. Chem. Commun., 2014, 50, 7024-7027.31. Yingqiang Zhao, Ming-Yue Ma, Guan-Wei Cui*, Xi-Feng Shi, Feng-Yun Han, Xin-Yuan Xia, Bo Tang*. A New Strategy to Realize Efficient Spacial Charge Separation on Carbonaceous Photocatalyst. Carbon, 2014, 73, 333-337.32. Xi-Feng Shi, Na Li, Ke Zhao, Guan-Wei Cui, Ying-Qiang Zhao, Ming-Yue Ma, Ke-Hua Xua, Ping Li, Yu-Bin Dong*, Bo Tang*. A dye-sensitized FeOOH-CNT photocatalyst with three electron transfer channels regulated by hydrogen bonding. Appl. Catal. B: Environ., 2013, 136-137, 334-340. 1、山東省科技廳項(xiàng)目：新型、高效農(nóng)藥、醫(yī)藥中間體原料的合成，2003年鑒定，成果水平為國(guó)際領(lǐng)先。2、山東省技廳項(xiàng)目：中間體三氟甲基水楊酸研究，2003年鑒定，成果水平為國(guó)際領(lǐng)先。3、山東省科技廳項(xiàng)目：固定化床催化生產(chǎn)腈類、酮類農(nóng)藥、醫(yī)藥中間體的新工藝，2003年鑒定，成果水平為國(guó)際領(lǐng)先。4、山東省教育廳項(xiàng)目：高效低毒醫(yī)藥農(nóng)藥中間體2-羥基-4-三氟甲基苯甲酸的合成，2003年鑒定，成果水平為國(guó)際領(lǐng)先。5、教育部高等學(xué)校骨干教師資助計(jì)劃：新型雙波段光能轉(zhuǎn)換薄膜材料的研究與應(yīng)用，2004 年鑒定，成果水平為國(guó)際先進(jìn)。6、濟(jì)南市青年科技明星計(jì)劃：加強(qiáng)農(nóng)作物光合作用的新材料研究及應(yīng)用，2004年鑒定，成果水平為國(guó)際先進(jìn)水平。7、山東省科技發(fā)展計(jì)劃發(fā)展項(xiàng)目：復(fù)合與單核雙波段光能轉(zhuǎn)換材料的中試生產(chǎn)及生態(tài)棚膜新產(chǎn)品的研發(fā)，國(guó)際先進(jìn)水平。20078、山東省科技廳科技攻關(guān)項(xiàng)目：含氟中間體電化學(xué)合成清潔生產(chǎn)工藝的研究與應(yīng)用，國(guó)際領(lǐng)先水平。20079、山東省教育廳重點(diǎn)項(xiàng)目：藥物中間體三氟甲基苯胺催化法綠色生產(chǎn)新工藝研究，國(guó)際先進(jìn)水平。200710、調(diào)控光合作用仿生態(tài)光能轉(zhuǎn)換材料的研制及其在農(nóng)作物種植中的應(yīng)用，國(guó)際領(lǐng)先。2008 一、 發(fā)展提出綠色化工理論模型和創(chuàng)新生產(chǎn)工藝發(fā)展了美國(guó)科學(xué)家Trost的原子利用率理論，提出了原子利用率有效值理論模型，并將這一理論模型應(yīng)用在污染排放嚴(yán)重的化肥及精細(xì)化學(xué)品生產(chǎn)領(lǐng)域。建立了40余種產(chǎn)品的新的清潔生產(chǎn)技術(shù)，從源頭上最大程度減少了污染物排放?！ ?.磷礦粉直接法生產(chǎn)N、P、K硫基或氯基三元復(fù)合肥新工藝研究研制開發(fā)出“磷礦粉直接法生產(chǎn)N、P、K硫基或氯基三元復(fù)合肥新工藝”。該技術(shù)解決了傳統(tǒng)生產(chǎn)工藝的磷石膏堆積的環(huán)境污染問題，原子利用率有效值達(dá)到100%，成為復(fù)合肥清潔生產(chǎn)工藝的典范。累計(jì)創(chuàng)產(chǎn)值18.3億元,利稅1.8億元,產(chǎn)生了顯著的經(jīng)濟(jì)社會(huì)效益。2001年獲國(guó)家科技進(jìn)步二等獎(jiǎng)、山東省科技進(jìn)步一等獎(jiǎng)。項(xiàng)目的實(shí)施，在一定程度上解決了我國(guó)當(dāng)時(shí)高品質(zhì)N、P、K復(fù)合肥依賴進(jìn)口的問題，極大促進(jìn)了復(fù)合肥行業(yè)的發(fā)展，提高了農(nóng)作物的產(chǎn)量和農(nóng)民增收。項(xiàng)目實(shí)施地山東省臨沂地區(qū)，已成為全國(guó)復(fù)合肥生產(chǎn)基地。唐波教授因此榮獲山東省“富民興魯”勞動(dòng)獎(jiǎng)?wù)潞褪 皟?yōu)秀專業(yè)技術(shù)人員”，成為首批山東省有突出貢獻(xiàn)的中青年專家?！ ?.重要農(nóng)藥、醫(yī)藥中間體的綠色化工生產(chǎn)技術(shù)集成研究唐波教授課題組通過新型高活性、長(zhǎng)壽命催化劑及反應(yīng)助劑的研制和新型清潔電合成工藝的應(yīng)用，完成了38種重要農(nóng)藥、醫(yī)藥中間體的清潔生產(chǎn)，實(shí)現(xiàn)了原子利用率有效值的最大化，最大程度上控制了產(chǎn)品生產(chǎn)過程中帶來的環(huán)境污染，截至2006年已累計(jì)創(chuàng)產(chǎn)值3.13億元，利稅1.5億元。項(xiàng)目的實(shí)施為精細(xì)化學(xué)品清潔生產(chǎn)起到了良好的示范作用，取得了顯著的經(jīng)濟(jì)社會(huì)效益。該成果2004年獲山東省科技進(jìn)步一等獎(jiǎng)，2006年獲國(guó)家科技進(jìn)步二等獎(jiǎng)，2007年獲山東省技術(shù)發(fā)明二等獎(jiǎng)、山東省發(fā)明創(chuàng)業(yè)特等獎(jiǎng)、國(guó)家第三屆發(fā)明創(chuàng)業(yè)獎(jiǎng)。唐波教授因此榮獲2007年“山東省先進(jìn)工作者”稱號(hào)。 二、“光生態(tài)”新型棚膜應(yīng)用于農(nóng)業(yè)生產(chǎn)，實(shí)現(xiàn)現(xiàn)代生態(tài)農(nóng)業(yè) 根據(jù)植物光合作用原理，研究開發(fā)出“光生態(tài)”新型棚膜，減少農(nóng)業(yè)生產(chǎn)中農(nóng)藥、化肥的使用量，提高農(nóng)產(chǎn)品品質(zhì)，達(dá)到增產(chǎn)增收的效果，解決了現(xiàn)有轉(zhuǎn)光膜發(fā)光單一、透光率降低、因生產(chǎn)成本高推廣應(yīng)用受限等問題。2010年，該產(chǎn)品已在我國(guó)山東、安徽、河南、山西等地推廣應(yīng)用，累計(jì)實(shí)現(xiàn)農(nóng)作物種植面積4萬(wàn)多畝，農(nóng)產(chǎn)品收入6億元，以增產(chǎn)15%計(jì)算，農(nóng)戶增收9000萬(wàn)元，取得了顯著的經(jīng)濟(jì)社會(huì)效益，對(duì)于增加農(nóng)民收入，實(shí)現(xiàn)科技興農(nóng)，發(fā)展低碳經(jīng)濟(jì)，實(shí)現(xiàn)生態(tài)農(nóng)業(yè)具有重要意義。該成果獲山東省“百千萬(wàn)富民工程杯”金獎(jiǎng)，山東省專利獎(jiǎng)二等獎(jiǎng)；2010年，項(xiàng)目獲山東省技術(shù)發(fā)明一等獎(jiǎng)。 三、應(yīng)用于生物成像的分子及納米熒光探針的合成與應(yīng)用致力于新穎實(shí)用的分子、納米熒光探針研究，并將成果用于細(xì)胞及活體組織內(nèi)多種重要生命相關(guān)物質(zhì)的成像檢測(cè)。相關(guān)研究成果發(fā)表于J.Am.Chem.Soc.等世界知名的化學(xué)類綜合期刊，引起了國(guó)內(nèi)外同行的廣泛關(guān)注。研究成果被J.Am.Chem.Soc., Chem. Rev., Proc. Natl. Acad. Sci. USA, Angew. Chem. Int. Ed., Adv. Mater.等著名期刊多次引用。美國(guó)霍普金斯大學(xué)、東京大學(xué)、美國(guó)農(nóng)業(yè)部林產(chǎn)品實(shí)驗(yàn)室、法國(guó)、德國(guó)等多個(gè)科研機(jī)構(gòu)來函索要所合成的探針。研究成果獲2008年山東省自然科學(xué)一等獎(jiǎng)。 指導(dǎo)博士后10余名,已培養(yǎng)獲得博士學(xué)位的研究生14名，獲得碩士學(xué)位的研究生90余名，畢業(yè)的碩士生中有5人的畢業(yè)論文評(píng)選為山東省優(yōu)秀碩士論文，有1人的科研成果被評(píng)為2006年山東省首屆研究生優(yōu)秀科研創(chuàng)新成果一等獎(jiǎng)，有多人考入佐治亞州立大學(xué)、弗吉尼亞理工大學(xué)、新加坡國(guó)立大學(xué)、清華大學(xué)、北京大學(xué)、中國(guó)科學(xué)院、南開大學(xué)、南京大學(xué)的博士研究生或從事博士后研究，2006年被評(píng)為山東省首屆優(yōu)秀研究生指導(dǎo)教師。
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